ResidualVM is a program (based on ScummVM) that lets you run classic 3D adventure games on Windows, MacOS X and Linux. As of the current development build (0.0.8git), one game is supported, Grim Fandango. Additionally, Myst III is partially playable, and very preliminary work has been done on Escape from Monkey Island (but it's not playable at all yet).

Adventure Games Supported by ResidualVM:
LucasArts GrimE Games:

Released in 1998. Uncover a mystery of crime and corruption in the Land of the Dead.